ISDA: 32TC

Deposition Date 2026-07-23

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

32TC

Keywords:

PROTEIN BINDING

Title:

Crystal structure of the human SPRY domain-containing SOCS box protein SPSB4 bound to fragment Z104474228

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.56 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 2 2 21

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:SPRY domain-containing SOCS b
Chain IDs:A
Chain Length:208
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

60P

FLC

SO4

Primary Citation

Crystallographic fragment screening of a human E3 ligase

Randall, G.T, Costello, N.A, Koekemoer, L, von Delft, F.Show

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Primary Citation of related structures

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