ISDA: 32FD

Deposition Date 2026-07-08

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

32FD

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go (alternative conformation)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Engineered miniGo
Chain IDs:B (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:D(3) dopamine receptor,Dopami
Gene (Uniprot):DRD3
Chain IDs:A (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P35462 Pfam ID:PF00001

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:E (auth: S)
Chain Length:0
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

7RU

Primary Citation

The structure of the dopamine D 3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.

Hadas Yardeni, E, Kiss, D.J, Sanchez, J, Shavit, K, Szepesi Kovacs, D, Egyed, A, Vogt, C.D, Gaitonde, S.A, Glenn, J, Canals, M, Bouvier, M, Newman, A.H, Lane, J.R, Keseru, G.M, Shalev-Benami, M.Show

Sci Adv 12 eaef7411 eaef7411 (2026)

PMID: 42664351 DOI: 10.1126/sciadv.aef7411

Primary Citation of related structures

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