ISDA: 31OF

Deposition Date 2026-06-16

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

31OF

Keywords:

SUGAR BINDING PROTEIN

Title:

Crystal structure of the complex of galectin-8N-2,6-Anhydro-5-S-(beta-D-galactopyranosyl)-5-thio-D-altritol

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.24

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Galectin-8
Gene (Uniprot):LGALS8
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O00214 Pfam ID:PF00337

Primary Citation

Structural and Biophysical Characterization of C-Glycosylic 1,2-Thiodisaccharides Reveals Determinants of Selective Binding to Galectin-7 and Galectin-8N.

Tsagkarakou, A.S, Kantsadi, A.L, Theodoridou, V.I, Veliotis, N, Lazar, L, Jozsef, J, Juhasz, L, Kontopidis, G, Leffler, H, Nilsson, U.J, Somsak, L, Leonidas, D.D.Show

Chemmedchem 21 e70439 e70439 (2026)

PMID: 42603778 DOI: 10.1002/cmdc.70439

Primary Citation of related structures

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