ISDA: 31EZ

Deposition Date 2026-06-01

Release Date 2026-07-01

Last Version Date 2026-07-08

Entry Detail

PDB ID:

31EZ

Keywords:

MEMBRANE PROTEIN

Title:

UapA (Q408E) in MSP1E3D1 nanodiscs, Xanthine-bound state

Biological Source:

Source Organism(s):

Aspergillus nidulans FGSC A4 (Taxon ID: 227321)

Expression System(s):

Saccharomyces cerevisiae

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.48 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Uric acid-xanthine permease
Gene (Uniprot):uapA
Mutagens:Q408E
Chain IDs:A, B
Chain Length:520
Number of Molecules:2
Biological Source:Aspergillus nidulans FGSC A4

UniProt ID:Q07307 Pfam ID:PF00860

Ligand Molecules

ERG

MYR

XAN

Primary Citation

Cryo-EM of the eukaryotic purine transporter UapA demonstrates intramolecular and lipid regulation of transport.

Broutzakis, G, Pyrris, Y, Akrani, I, Neuhaus, A, Mikros, E, Diallinas, G, Gatsogiannis, C.Show

Proc.Natl.Acad.Sci.USA 123 e2513585123 e2513585123 (2026)

PMID: 42361038 DOI: 10.1073/pnas.2513585123

Primary Citation of related structures

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