ISDA: 31EL

Deposition Date 2026-05-29

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

31EL

Keywords:

VIRAL PROTEIN

Title:

NSP14 IN COMPLEX WITH LIGAND MAVDA-K-197

Biological Source:

Source Organism(s):

SARS-CoV-2 pseudovirus (Taxon ID: 3092168)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.77 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Guanine-N7 methyltransferase
Mutagens:D90A, E92A
Chain IDs:A, B
Chain Length:529
Number of Molecules:2
Biological Source:SARS-CoV-2 pseudovirus

Ligand Molecules

A1J82

EDO

SAH

Primary Citation

A new class of small-molecule inhibitors targeting the SARS-CoV-2 mRNA cap methyltransferase NSP14

Meyer, C, Garzia, A, Merritt, J, Freundlich, J.S, Hoffmann, H, Ashbrook, A.W, Zimmerman, M, Nelson, A.M, Davis, J.A, Balkovec, J, Murugan, M, Chang, C, Oswal, N, Penalva-Lopez, S, Sharma, V, Dolgov, E, Cangialosi, J, Sharma, P, Nitsche, J, Ganichkin, O, Steinbacher, S, Glickman, J.F, Rice, C.M, Perlin, D.S, Tuschl, T.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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