30AD image
Deposition Date 2026-04-16
Release Date 2026-09-02
Last Version Date 2026-09-16
Entry Detail
PDB ID:
30AD
Keywords:
IMMUNE SYSTEM
Title:
Complex between IgE-Fc and anti-IgE Fab aeFab81
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Oryctolagus cuniculus (Taxon ID: 9986)
Expression System(s):
Mus musculus, Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.20 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 31 2 1
30AD validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Immunoglobulin h
Gene (Uniprot):IGHE
Chain IDs:A, B
Chain Length:327
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P01854 Pfam ID:PF07654
Polymer Type:polypeptide(L)
Molecule:aeFab81 heavy chain
Chain IDs:C (auth: H)
Chain Length:216
Number of Molecules:1
Biological Source:Oryctolagus cuniculus
Polymer Type:polypeptide(L)
Molecule:aeFab81 light chain
Chain IDs:D (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:Oryctolagus cuniculus
Ligand Molecules
PEG
PG4
TRS
Primary Citation
Antibodies targeting a shared epitope exploit IgE allostery to drive distinct functional outcomes.
Proc.Natl.Acad.Sci.USA 123 e2613091123 e2613091123 (2026)
PMID: 42709784 DOI: 10.1073/pnas.2613091123
Primary Citation of related structures
30AD
Feedback Form
Name
Email
Institute
Feedback