ISDA: 30AC

Deposition Date 2026-04-16

Release Date 2026-09-02

Last Version Date 2026-09-16

Entry Detail

PDB ID:

30AC

Keywords:

IMMUNE SYSTEM

Title:

Complex between IgE-Fc and anti-IgE Fab aeFab67

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Oryctolagus cuniculus (Taxon ID: 9986)

Expression System(s):

Mus musculus, Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.20 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Immunoglobulin h
Gene (Uniprot):IGHE
Chain IDs:A, B
Chain Length:327
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01854 Pfam ID:PF07654

Polymer Type:polypeptide(L)
Molecule:aeFab67 heavy chain
Chain IDs:C (auth: H), E (auth: C)
Chain Length:211
Number of Molecules:2
Biological Source:Oryctolagus cuniculus

Polymer Type:polypeptide(L)
Molecule:aeFab67 light chain
Chain IDs:D (auth: L), F (auth: D)
Chain Length:214
Number of Molecules:2
Biological Source:Oryctolagus cuniculus

Ligand Molecules

PG4

Primary Citation

Antibodies targeting a shared epitope exploit IgE allostery to drive distinct functional outcomes.

Davies, A.M, Drinkwater, N, Beavil, A.J, O'Dowd, V, Lightwood, D, Ceska, T, Henry, A.J, Sutton, B.J, McDonnell, J.M.Show

Proc.Natl.Acad.Sci.USA 123 e2613091123 e2613091123 (2026)

PMID: 42709784 DOI: 10.1073/pnas.2613091123

Primary Citation of related structures

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