ISDA: 2MU8

Deposition Date 2014-09-04

Release Date 2014-11-12

Last Version Date 2024-05-15

Entry Detail

PDB ID:

2MU8

Keywords:

CELL INVASION

Title:

Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum

Biological Source:

Source Organism(s):

Plasmodium falciparum (Taxon ID: 5833)

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MSP-2 peptide
Chain IDs:A
Chain Length:20
Number of Molecules:1
Biological Source:Plasmodium falciparum

UniProt ID:P50498

Ligand Molecules

Primary Citation

Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.

Cifuentes, G, Patarroyo, M.E, Urquiza, M, Ramirez, L.E, Reyes, C, Rodriguez, R.Show

J. Med. Chem. 46 2250 2253 (2003)

PMID: 12747797 DOI: 10.1021/jm020440w

Abstact

The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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