ISDA: 2HTO

Deposition Date 2006-07-26

Release Date 2006-08-08

Last Version Date 2026-08-12

Entry Detail

PDB ID:

2HTO

Keywords:

DNA

Title:

Ruthenium hexammine ion interactions with Z-DNA

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.54 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*DCP*DGP*DCP*DGP*DC
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*DTP*DGP*DCP*DGP*DC
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:

Ligand Molecules

NRU

Primary Citation

Hexammineruthenium(III) ion interactions with Z-DNA

Bharanidharan, D, Thiyagarajan, S, Gautham, N.Show

Acta Crystallogr.,Sect.F 63 1008 1013 (2007)

PMID: 18084080 DOI: 10.1107/S1744309107047781

Abstact

The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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