ISDA: 2AO7

Deposition Date 2005-08-12

Release Date 2006-08-08

Last Version Date 2024-12-25

Entry Detail

PDB ID:

2AO7

Keywords:

HYDROLASE

Title:

Adam10 Disintegrin and cysteine- rich domain

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.90 Å

R-Value Free:

0.28

R-Value Work:

0.26

Space Group:

I 41 3 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ADAM 10
Gene (Uniprot):ADAM10
Chain IDs:A
Chain Length:192
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:Q10741 Pfam ID:PF00200, PF21299

Ligand Molecules

SO4

Primary Citation

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

Janes, P.W, Saha, N, Barton, W.A, Kolev, M.V, Wimmer-Kleikamp, S.H, Nievergall, E, Blobel, C.P, Himanen, J.-P, Lackmann, M, Nikolov, D.B.Show

Cell 123 291 304 (2005)

PMID: 16239135 DOI: 10.1016/j.cell.2005.08.014

Abstact

Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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