ISDA: 29ZZ

Deposition Date 2026-04-16

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

29ZZ

Keywords:

MOTOR PROTEIN

Title:

Human smooth muscle myosin motor domain co-crystallized with the S(-)2501 inhibitor, MgADP-VO4 form.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 31

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Myosin-11
Gene (Uniprot):MYH11
Chain IDs:A
Chain Length:794
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P35749

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MLY	A	LYS	modified residue

Ligand Molecules

A1IMH

ADP

DMS

EDO

GOL

VO4

Primary Citation

Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades

Penzes, M, Winternitz, M, Horvath, A.I, Mastitskaya, S, Awan, U, Szimler, T, Glaser, C, Kikuti, C.M, Juille, M, Heidsieck, L, Rauscher, A.A, Balint, T, Nagy, D, Radovits, T, Sayour, A.A, Gibson, C.M, Houdusse, A, Gyimesi, M, Malnasi-Csizmadia, A.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-11171-6

Primary Citation of related structures

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