ISDA: 29XL

Deposition Date 2026-04-13

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

29XL

Keywords:

FLAVOPROTEIN

Title:

Full-length MICAL1 in the oxidized and autoinhibited state vitrified in the presence of NADPH

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:[F-actin]-monooxygenase MICAL
Gene (Uniprot):MICAL1
Chain IDs:A
Chain Length:1067
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8TDZ2 EC:1.14.13.225

Ligand Molecules

FAD

Primary Citation

NADPH gating and F-actin engagement define the structural bases of MICAL1 autoinhibition and activation.

Ballabio, F, Minari, A, Bonnet, D.M.V, Graziadei, A, Di Ianni, A, Nobile, M, Tedeschi, G, Camilloni, C, Chaves-Sanjuan, A, Vanoni, M.A.Show

Arch.Biochem.Biophys. ? 111023 111023 (2026)

PMID: 42863552 DOI: 10.1016/j.abb.2026.111023

Primary Citation of related structures

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