ISDA: 29VY

Deposition Date 2026-04-10

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

29VY

Keywords:

OXIDOREDUCTASE

Title:

Structure of Tetrahydrocannabinolic acid synthase(THCAS) in complex with FAD

Biological Source:

Source Organism(s):

Cannabis sativa (Taxon ID: 3483)

Expression System(s):

Komagataella pastoris

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.33 Å

R-Value Free:

0.30

R-Value Work:

0.24

R-Value Observed:

0.25

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tetrahydrocannabinolic acid s
Gene (Uniprot):THCAS
Chain IDs:A, B, C
Chain Length:545
Number of Molecules:3
Biological Source:Cannabis sativa

UniProt ID:Q8GTB6 EC:1.21.3.7

Ligand Molecules

FAD

NAG

Primary Citation

X-ray crystal structures of the cannabinoid synthases CBCAS, CBDAS and THCAS

Domenech, J, King, A, Byrne, E, Cartwright, J, Grogan, G.Show

Curr Res Struct Biol 12 100197 ? (2026)

DOI: 10.1016/j.crstbi.2026.100197

Primary Citation of related structures

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