29TC image
Deposition Date 2026-04-07
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
29TC
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of homo-hexameric hLRRC8A double mutation I2C/L402W
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.54 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
29TC validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Volume-regulated anion channe
Gene (Uniprot):LRRC8A
Mutagens:I2C,L402W
Chain IDs:A, B, C, D, E, F
Chain Length:811
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:Q8IWT6 Pfam ID:PF12534, PF13855, PF23598
Ligand Molecules
NA
Primary Citation
The intracellular subdomain of the volume regulated anion channel subunit LRRC8A is a hotspot of channel activation
To Be Published ? ? ? (2026)
DOI: 10.1038/s41467-026-77507-y
Primary Citation of related structures
29TC
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