ISDA: 29RX

Deposition Date 2026-04-02

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

29RX

Keywords:

TRANSFERASE

Title:

Crystal structure of JAK2 JH1 in complex with ADP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.34

R-Value Work:

0.30

R-Value Observed:

0.30

Space Group:

I 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase JAK2
Gene (Uniprot):JAK2
Chain IDs:A, B, C
Chain Length:316
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:O60674 Pfam ID:PF07714 EC:2.7.10.2

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

ADP

Primary Citation

Janus kinase 2 activation loop as a regulator of catalysis and trans-activation.

Miao, Y, Mykuliak, V.V, Hubbard, S.R, Silvennoinen, O, Hytonen, V, Haikarainen, T.Show

Int.J.Biol.Macromol. 374 153276 153276 (2026)

PMID: 42409141 DOI: 10.1016/j.ijbiomac.2026.153276

Primary Citation of related structures

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