ISDA: 29MJ

Deposition Date 2026-03-23

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

29MJ

Keywords:

TRANSFERASE

Title:

Akt1 mutant in complex with miransertib (ARQ 092)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.23

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RAC-alpha serine/threonine-pr
Gene (Uniprot):AKT1
Chain IDs:A, B, C
Chain Length:445
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P31749 Pfam ID:PF00169, PF00069, PF00433 EC:2.7.11.1

Ligand Molecules

6S1

EDO

GOL

Primary Citation

Selective covalent-allosteric tools to dissect Akt2

Quambusch, L, D'Angelo, D, Kirschner, T, Beerbaum, M, Depta, L, Schnecke, F, Niggenaber, J, Brandherm, S, Weisner, J, Mueller, M.P, Rauh, D.Show

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Primary Citation of related structures

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