ISDA: 29LK

Deposition Date 2026-03-20

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

29LK

Keywords:

TRANSFERASE

Title:

High-resolution structure of human SHMT2 in complex with PLP-Ser (external aldimine)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.26 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Serine hydroxymethyltransfera
Chain IDs:A, B, C, D
Chain Length:476
Number of Molecules:4
Biological Source:Homo sapiens

Ligand Molecules

EDO

PEG

PLS

TRS

Primary Citation

High-resolution structures of human SHMT2

Warlich, A, Ruszkowski, M, Nawrot, D.Show

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