ISDA: 29DA

Deposition Date 2026-03-06

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

29DA

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of enterovirus D68-3Cpro in complex with RK-496

Biological Source:

Source Organism(s):

Enterovirus (Taxon ID: 12059)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.08 Å

R-Value Free:

0.23

R-Value Work:

0.20

Space Group:

P 31 2 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Genome polyprotein
Chain IDs:A
Chain Length:189
Number of Molecules:1
Biological Source:Enterovirus

Ligand Molecules

A1JQY

Primary Citation

Structure-based macrocyclization of alpha-ketoamides leads to potent inhibitors of coronaviral and enteroviral proteases.

Akula, R.K, El Kilani, H, Metzen, A, Joshi, S, Durmaz, H, Veenstra, R, Roske, J, Hurdiss, D.L, Van Kuppeveld, F.J.M, Rox, K, Hilgenfeld, R, Bronstrup, M.Show

Commun Chem 9 ? ? (2026)

PMID: 42562838 DOI: 10.1038/s42004-026-02151-y

Primary Citation of related structures

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