ISDA: 29BY

Deposition Date 2026-03-05

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

29BY

Keywords:

RNA BINDING PROTEIN

Title:

Cryo-EM structure of human DHX9 in complex with ATX-968 and ADP.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent RNA helicase A
Gene (Uniprot):DHX9
Chain IDs:A
Chain Length:1010
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q08211 EC:3.6.4.13

Ligand Molecules

A1BKX

ADP

Primary Citation

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Read, B.J, Ewens, C, Gigante, F, Thomas, J, Felisberto-Rodrigues, C, Alvarez Peres, S, Tighe, C, de Las Heras Ruiz, E, Schiemann, K, Malcolm, A.G, McAndrew, P.C, Stubbs, M, Patani, H, Costa, H.D.S, Stoodley, K, Pickard, L, Busch, M, Gunnell, E, Silva, S, Knopp, A, Hallett, S.T, Augustin, M, Lammens, A, Carter, M, Meniconi, M, Ballarotto, M, Ainsley, J, Meister, P, Sethi, D, Burke, R, Scarpino, A, Le Bihan, Y.V, Gradler, U, Blagg, J, Workman, P, Clarke, P.A, Blum, A, Esdar, C, Bhalay, G, van Montfort, R.L.M.Show

J.Med.Chem. 69 18277 18299 (2026)

PMID: 42593941 DOI: 10.1021/acs.jmedchem.6c00732

Primary Citation of related structures

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