ISDA: 28ZR

Deposition Date 2026-03-03

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

28ZR

Keywords:

RNA BINDING PROTEIN

Title:

Crystal structure of human DHX8 in complex with compound 51 and ADP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.45 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:ATP-dependent RNA helicase DH
Chain IDs:A, B, C, D
Chain Length:680
Number of Molecules:4
Biological Source:Homo sapiens

Ligand Molecules

A1J1J

ADP

DMS

EDO

Primary Citation

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Read, B.J, Ewens, C, Gigante, F, Thomas, J, Felisberto-Rodrigues, C, Alvarez Peres, S, Tighe, C, de Las Heras Ruiz, E, Schiemann, K, Malcolm, A.G, McAndrew, P.C, Stubbs, M, Patani, H, Costa, H.D.S, Stoodley, K, Pickard, L, Busch, M, Gunnell, E, Silva, S, Knopp, A, Hallett, S.T, Augustin, M, Lammens, A, Carter, M, Meniconi, M, Ballarotto, M, Ainsley, J, Meister, P, Sethi, D, Burke, R, Scarpino, A, Le Bihan, Y.V, Gradler, U, Blagg, J, Workman, P, Clarke, P.A, Blum, A, Esdar, C, Bhalay, G, van Montfort, R.L.M.Show

J.Med.Chem. 69 18277 18299 (2026)

PMID: 42593941 DOI: 10.1021/acs.jmedchem.6c00732

Primary Citation of related structures

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