ISDA: 28OI

Deposition Date 2026-02-11

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

28OI

Keywords:

CYTOSOLIC PROTEIN

Title:

The crystal structure of zebrafish HDAC6 CD2 in complex with compound 2

Biological Source:

Source Organism(s):

Danio rerio (Taxon ID: 7955)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.98 Å

R-Value Free:

0.28

R-Value Work:

0.22

R-Value Observed:

0.23

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone deacetylase 6
Gene (Uniprot):hdac6
Chain IDs:A, B
Chain Length:364
Number of Molecules:2
Biological Source:Danio rerio

UniProt ID:F8W4B7 Pfam ID:PF00850

Ligand Molecules

A1JZP

Primary Citation

Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 In Vivo.

Ripa, L, Cassani, C, Hughes, G, Ranieri, B, Ullah, V, Zambelloni, R, Andreasson, T, Collins, M, Lindberg, B, Llinas, A, Pehrson, R, Barylyuk, K, Johansson, J, Ek, M, Gunnarsson, A, Jung, B, Lundqvist, S, Noven, A, Sandmark, J, Astrand, A.Show

Acs Med.Chem.Lett. 17 1294 1302 (2026)

PMID: 42305196 DOI: 10.1021/acsmedchemlett.6c00086

Primary Citation of related structures

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