ISDA: 28MR

Deposition Date 2026-02-08

Release Date 2026-03-11

Last Version Date 2026-03-18

Entry Detail

PDB ID:

28MR

Keywords:

METAL TRANSPORT

Title:

X-ray structure of the adduct between human serum transferrin with Fe3+ bound at the C-lobe and diruthenium tetraacetate chloride

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.26 Å

R-Value Free:

0.23

R-Value Work:

0.17

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serotransferrin
Gene (Uniprot):TF
Chain IDs:A
Chain Length:679
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P02787 Pfam ID:PF00405

Ligand Molecules

ACT

GOL

MLI

Primary Citation

Ru and Rh binding sites in the structure of human serum transferrin with Fe 3+ bound at the C-lobe.

Banneville, A.S, Ferraro, G, D'Elia, R, Cornaciu-Hoffmann, I, Pica, A, Merlino, A.Show

Dalton Trans 55 4051 4056 (2026)

PMID: 41738634 DOI: 10.1039/d6dt00205f

Abstact

Ru and Rh binding sites in the structure of human serum transferrin with Fe(3+) bound at the C-lobe were identified by X-ray crystallography. Several His side chains and one Met are involved in the recognition of the metal ions by the protein.

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Primary Citation of related structures

Abstact

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