28MQ image
Deposition Date 2026-02-08
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
28MQ
Title:
Cryo-EM structure of UBA6-FAT10Dha-UBE2Z trapped ternary complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
Resolution:
3.04 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-conjugating enzyme
Gene (Uniprot):UBE2Z
Chain IDs:A
Chain Length:356
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like modifier-activ
Gene (Uniprot):UBA6
Chain IDs:B
Chain Length:1054
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Ubiquitin D
Gene (Uniprot):UBD
Mutagens:C7T, C9T, C134L, C160S, C162S
Chain IDs:C
Chain Length:167
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes.
Nat Commun 17 ? ? (2026)
PMID: 42733088 DOI: 10.1038/s41467-026-76603-3
Primary Citation of related structures
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