ISDA: 28JS

Deposition Date 2026-02-03

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

28JS

Keywords:

DNA BINDING PROTEIN

Title:

Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (composite map)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.32 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription and DNA
Gene (Uniprot):ERCC3
Chain IDs:A
Chain Length:797
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P19447 Pfam ID:PF13625, PF04851, PF16203

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TFIIH basal transcription fac
Gene (Uniprot):ERCC2
Chain IDs:B
Chain Length:771
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P18074 Pfam ID:PF06733, PF06777, PF13307 EC:3.6.4.12

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription factor
Gene (Uniprot):GTF2H1
Chain IDs:C
Chain Length:591
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P32780 Pfam ID:PF08567, PF03909

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription factor
Gene (Uniprot):GTF2H4
Chain IDs:D
Chain Length:462
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q92759 Pfam ID:PF03849, PF18307

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription factor
Gene (Uniprot):GTF2H2
Chain IDs:E
Chain Length:395
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13888 Pfam ID:PF04056, PF07975

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription factor
Gene (Uniprot):GTF2H3
Chain IDs:F
Chain Length:308
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13889 Pfam ID:PF03850

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:General transcription factor
Gene (Uniprot):GTF2H5
Chain IDs:G
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6ZYL4 Pfam ID:PF06331

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CDK-activating kinase assembl
Gene (Uniprot):MNAT1
Chain IDs:H
Chain Length:309
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51948 Pfam ID:PF17121, PF06391, PF25811

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA repair protein complement
Gene (Uniprot):XPC
Chain IDs:I
Chain Length:940
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q01831 Pfam ID:PF03835, PF10403, PF10404, PF10405

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine-specific demethylase R
Gene (Uniprot):RAD23B
Chain IDs:J
Chain Length:409
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P54727 Pfam ID:PF00240, PF00627, PF09280

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Centrin-2
Gene (Uniprot):CETN2
Chain IDs:K
Chain Length:172
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P41208 Pfam ID:PF13499

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (Cy5)
Chain IDs:L
Chain Length:71
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (biotinylated)
Chain IDs:M
Chain Length:92
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules