ISDA: 28JC

Deposition Date 2026-02-03

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

28JC

Keywords:

GENE REGULATION

Title:

RNA polymerase II bound to RPAP2 and Gdown1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens, Escherichia coli, Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.94 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:K (auth: A)
Chain Length:1970
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:L (auth: B)
Chain Length:1174
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:M (auth: C)
Chain Length:275
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:A (auth: D)
Chain Length:142
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Chain IDs:B (auth: E)
Chain Length:210
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Chain IDs:C (auth: F)
Chain Length:127
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:D (auth: G)
Chain Length:172
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Chain IDs:E (auth: H)
Chain Length:150
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:F (auth: I)
Chain Length:125
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Chain IDs:G (auth: J)
Chain Length:67
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:H (auth: K)
Chain Length:117
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Chain IDs:I (auth: L)
Chain Length:58
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:J (auth: M)
Chain Length:368
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Putative RNA polymerase II su
Chain IDs:N
Chain Length:612
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1.

Schmitzova, J, Zhan, Y, Rengachari, S, Grabbe, F, Dybkov, O, Urlaub, H, Lidschreiber, M, Dienemann, C, Cramer, P.Show

Nat Commun 17 ? ? (2026)

PMID: 42557252 DOI: 10.1038/s41467-026-76334-5

Primary Citation of related structures

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