ISDA: 28IZ

Deposition Date 2026-02-02

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

28IZ

Keywords:

MEMBRANE PROTEIN

Title:

Structure of the human two pore domain potassium ion channel TASK-3 L122V mutant (K2P9.1)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.83 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Potassium channel subfamily K
Mutagens:L122V
Chain IDs:A, B
Chain Length:267
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Y01

Primary Citation

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies.

Crowther, K.M, Jouen-Tachoire, T.R.H, Proks, P, Hall, P.R, Veale, E.L, Sormann, J, Rodstrom, K.E.J, Muller, T, Wortmann, S.B, Barisic, N, Hauser, N, Salpietro, V, Forsyth, R, Williams, L, Derrabi, N, Bacino, C.A, Rosenfeld, J.A, Houlden, H, Newstead, S, Wright, C.F, Fasham, J, Mathie, A.A, Maroofian, R, Tucker, S.J.Show

J.Gen.Physiol. 158 ? ? (2026)

PMID: 42560358 DOI: 10.1085/jgp.202613989

Primary Citation of related structures

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