ISDA: 28IY

Deposition Date 2026-02-02

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

28IY

Keywords:

MOTOR PROTEIN

Title:

Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of JIP1 at 2.13 Angstrom resolution

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Lama glama (Taxon ID: 9844)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.13 Å

R-Value Free:

0.24

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Kinesin light chain,C-Jun-ami
Gene (Uniprot):Mapk8ip1, Klc1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:Q5UE59,A0A9J7H4Y6 Pfam ID:PF13424, PF13374

Polymer Type:polypeptide(L)
Molecule:Nanobody
Chain IDs:B (auth: F)
Chain Length:0
Number of Molecules:1
Biological Source:Lama glama

Primary Citation

Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features.

Peirano, E, O'Regan, L, Harrer, P, Dzinovic, I, Chegkazi, M.S, Havrankova, P, Brunet, T, Capolino, R, Cesario, C, Ferro, S, Hammar, E, Ha-Vinh Leuchter, R, Indelicato, E, Jacob, M, Kunc, L, Margot, H, Marin, O, Mazurkiewicz-Beldzinska, M, Mencacci, N.E, Novelli, A, Orec, L, Poschmann, M, Sitzberger, A, Sorrentino, U, Spanjaard, M, Wagner, M, Krygier, M, Boesch, S, Necpal, J, Skorvanek, M, Gilbert, D.L, Jech, R, Dodding, M, Steiner, R.A, Zech, M.Show

Ebiomedicine 129 106358 106358 (2026)

PMID: 42372486 DOI: 10.1016/j.ebiom.2026.106358

Primary Citation of related structures

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