ISDA: 28IL

Deposition Date 2026-02-02

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

28IL

Keywords:

IMMUNE SYSTEM

Title:

P1-15 T-cell Receptor bound to HLA A*2402-NF9 pMHC complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.10 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 31 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):HLA-A
Chain IDs:A, F
Chain Length:276
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:A0A411J078

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B, G
Chain Length:100
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61769 Pfam ID:PF07654

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:C, H
Chain Length:9
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:P1-15 T-cell Receptor Alpha C
Chain IDs:D, I
Chain Length:204
Number of Molecules:2
Biological Source:Homo sapiens

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:P1-15 T-cell Receptor Beta Ch
Chain IDs:E, J
Chain Length:245
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Position-5-driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T cell escape.

Nakama, T, Wall, A, Dolton, G, Tan, L.R, Thomas, H, Hamana, H, Aritsu, Y, Tan, T.S, Toyoda, M, Goto, Y, Li, H, Kitamatsu, M, Udaka, K, Miyashita, Y, Oshiumi, H, Nakamura, K, Nagasaki, Y, Minami, R, Nakata, H, Rizkallah, P.J, Kishi, H, Ueno, T, Sewell, A.K, Motozono, C.Show

JCI Insight 11 ? ? (2026)

PMID: 41842944 DOI: 10.1172/jci.insight.202235

Primary Citation of related structures

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