28HY image
Deposition Date 2026-02-01
Release Date 2026-10-14
Last Version Date 2026-10-14
Entry Detail
PDB ID:
28HY
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.27 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
28HY validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein 45A
Gene (Uniprot):TMEM45A
Chain IDs:A, B, C, D
Chain Length:275
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9NWC5
Ligand Molecules
A1JXZ
UNX
Primary Citation
Cryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate.
J.Struct.Biol. 218 108378 108378 (2026)
PMID: 42800517 DOI: 10.1016/j.jsb.2026.108378

Abstact

The orphan transmembrane protein 45 A (TMEM45A) is highly expressed in keratinocytes as well as cancer cells under hypoxic conditions, where it contributes to metastasis and chemoresistance. The structure of human TMEM45A, determined with single-particle cryo-electron microscopy (cryo-EM) to 3.27 A, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices (TMHs) of each protomer assemble to form a central hydrophobic tunnel containing a 2-hydroxypalmitate.

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Primary Citation of related structures
28HY
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