27UH image
Deposition Date 2026-06-12
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
27UH
Keywords:
DE NOVO PROTEIN
Title:
Crystal structure of a de novo-designed VHH targeting S100A4
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Cricetulus griseus, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.82 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
P 21 21 21
27UH validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:S100A4_VHH-N20
Chain IDs:A, C, E, G
Chain Length:131
Number of Molecules:4
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein S100-A4
Gene (Uniprot):S100A4
Chain IDs:B, D, F, H
Chain Length:102
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P26447 Pfam ID:PF01023
Ligand Molecules
CA
GOL
PEG
Primary Citation
High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation
To Be Published ? ? ? (?)
Primary Citation of related structures
27UH
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