ISDA: 26QH

Deposition Date 2026-05-11

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

26QH

Keywords:

TRANSFERASE

Title:

Cryo-EM structure of human UGCG bound to Eliglustat

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.23 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Ceramide glucosyltransferase
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1E94

Primary Citation

Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG

Wu, C, Jin, S, Xu, J, Wang, J.J, Guo, X, Li, Y, Cao, Z, Jiang, M, Yuan, Q, Hu, W, Li, C, Xu, Y, Wang, M.W, Jiang, Y, Xu, H.E.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-10927-4

Primary Citation of related structures

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