ISDA: 26JZ

Deposition Date 2026-05-04

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

26JZ

Keywords:

RNA BINDING PROTEIN/RNA

Title:

Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with 5'/3' vRNA dual-promotor

Biological Source:

Source Organism(s):

Orthonairovirus haemorrhagiae (Taxon ID: 3052518)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.65 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:RNA-directed RNA polymerase L
Chain IDs:A
Chain Length:3974
Number of Molecules:1
Biological Source:Orthonairovirus haemorrhagiae

Polymer Type:polyribonucleotide
Molecule:5' vRNA promoter
Chain IDs:B
Chain Length:15
Number of Molecules:1
Biological Source:Orthonairovirus haemorrhagiae

Polymer Type:polyribonucleotide
Molecule:3' vRNA promoter
Chain IDs:C
Chain Length:26
Number of Molecules:1
Biological Source:Orthonairovirus haemorrhagiae

Ligand Molecules

Primary Citation

Cryo-EM structures of CCHFV polymerase reveal a stepwise initiation stabilization pathway and a dual-site inhibition mechanism

Yang, K, Wu, H, Liu, X, Ma, J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form