ISDA: 25YR

Deposition Date 2026-04-23

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

25YR

Keywords:

CELL INVASION

Title:

High-resolution crystal structure of Arp2/3 complex inhibitor Arpin

Biological Source:

Source Organism(s):

Danio rerio (Taxon ID: 7955)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 65

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Arpin
Gene (Uniprot):arpin
Chain IDs:A (auth: B), B (auth: A)
Chain Length:216
Number of Molecules:2
Biological Source:Danio rerio

UniProt ID:Q1LWJ6 Pfam ID:PF10574

Primary Citation

Structural basis of arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement.

Liu, L, Zhang, X, Zhu, Y, Pu, M, Geng, Y, Wang, M, Zhang, R, Ge, S, Ye, S.Show

Protein Cell ? ? ? (2026)

PMID: 41875392 DOI: 10.1093/procel/pwag021

Primary Citation of related structures

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