25VX image
Deposition Date 2026-04-20
Release Date 2026-05-06
Last Version Date 2026-05-06
Entry Detail
PDB ID:
25VX
Keywords:
TRANSCRIPTION
Title:
Crystal Structure of MYST histone acetyltransferase KAT6A in complex with inhibitor Compound 9
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.29 Å
R-Value Free:
0.26
R-Value Work:
0.19
R-Value Observed:
0.20
Space Group:
P 21 21 21
25VX validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone acetyltransferase KAT
Gene (Uniprot):KAT8
Mutagens:Y579H,A645S,L648M,T649I,K660R,I702N
Chain IDs:A
Chain Length:271
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H7Z6 Pfam ID:PF17772, PF01853 EC:2.3.1.48
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
ALY A LYS modified residue
Ligand Molecules
A1MGC
Primary Citation
Crystal Structure of MYST histone acetyltransferase KAT6A in complex with Compound 9
To Be Published ? ? ? (?)
Primary Citation of related structures
22TG
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