ISDA: 25SB

Deposition Date 2026-04-16

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

25SB

Keywords:

TOXIN/IMMUNE SYSTEM

Title:

CyroEM structure of the complex between Shiga toxin Stx1a B subunit and neutralising Fab fragment of RDS059

Biological Source:

Source Organism(s):

Escherichia coli O157:H7 (Taxon ID: 83334)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Cricetulus griseus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Shiga toxin subunit B
Chain IDs:A, D, G (auth: E), J (auth: F), M (auth: G)
Chain Length:71
Number of Molecules:5
Biological Source:Escherichia coli O157:H7

Polymer Type:polypeptide(L)
Molecule:Heavy chain of RDS059 Fab
Chain IDs:B, E (auth: H), H (auth: I), K (auth: J), N (auth: K)
Chain Length:227
Number of Molecules:5
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Light chain of RDS059 Fab
Chain IDs:C, F (auth: L), I (auth: M), L (auth: N), O
Chain Length:214
Number of Molecules:5
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

CyroEM structure of the complex between Shiga toxin Stx1a B subunit and neutralising Fab fragment of RDS059

Chen, S.D, Li, X.Show

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