ISDA: 25RG

Deposition Date 2026-04-15

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

25RG

Keywords:

TOXIN/IMMUNE SYSTEM

Title:

CyroEM structure of the complex between Shiga toxin Stx1a B subunit and neutralising Fab fragment of RDS045

Biological Source:

Source Organism(s):

Shigella dysenteriae (Taxon ID: 622)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Cricetulus griseus

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Shiga toxin subunit B
Chain IDs:A, D, G (auth: E), J (auth: F), M (auth: G)
Chain Length:73
Number of Molecules:5
Biological Source:Shigella dysenteriae

Polymer Type:polypeptide(L)
Molecule:Heavy chain of RDS045 Fab
Chain IDs:B, E (auth: H), H (auth: I), K (auth: J), N (auth: K)
Chain Length:220
Number of Molecules:5
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Light chain of RDS045 Fab
Chain IDs:C, F (auth: L), I (auth: M), L (auth: N), O
Chain Length:216
Number of Molecules:5
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

CyroEM structure of the complex between Shiga toxin Stx1a B subunit and neutralising RDS045(pentamer)

Chen, S.D, Li, X.Show

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