ISDA: 25QP

Deposition Date 2026-04-14

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

25QP

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM Structure of PLPP3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phospholipid phosphatase 3
Gene (Uniprot):PLPP3
Chain IDs:A, B, C, D
Chain Length:318
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:O14495 Pfam ID:PF01569 EC:3.1.3.4

Ligand Molecules

LBN

NAG

PX2

Primary Citation

Structural basis of PLPP3-mediated lipid phosphate dephosphorylation and its role in melanoma.

Wu, Y, Xiao, D, Li, X, Wang, K, Zhang, H, Zhao, Y, Wu, D, Qi, R, Zhou, M, Han, H, Long, T.Show

Nat Commun ? ? ? (2026)

PMID: 42477009 DOI: 10.1038/s41467-026-75824-w

Primary Citation of related structures

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