ISDA: 25IJ

Deposition Date 2026-04-06

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

25IJ

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Paraponera clavata (Taxon ID: 55425)

Expression System(s):

Homo sapiens, Synthetic construct

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium channel protein type 8
Gene (Uniprot):SCN8A
Chain IDs:A
Chain Length:1980
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UQD0 Pfam ID:PF00520, PF11933, PF06512, PF24609

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Delta-paraponeritoxin-Pc1a
Chain IDs:B
Chain Length:26
Number of Molecules:1
Biological Source:Paraponera clavata

UniProt ID:P41736

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium channel regulatory sub
Gene (Uniprot):SCN1B
Chain IDs:C
Chain Length:173
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q07699 Pfam ID:PF07686

Ligand Molecules