25II image
Deposition Date 2026-04-06
Release Date 2026-05-20
Last Version Date 2026-05-20
Entry Detail
PDB ID:
25II
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human Nav1.6 in complex with Iota-Conotoxin RXIA
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Conus radiatus (Taxon ID: 61198)
Expression System(s):
Homo sapiens, Conus radiatus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
25II validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium channel protein type 8
Gene (Uniprot):SCN8A
Chain IDs:A
Chain Length:1980
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UQD0 Pfam ID:PF00520, PF11933, PF06512, PF24609
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium channel regulatory sub
Gene (Uniprot):SCN1B
Chain IDs:B (auth: C)
Chain Length:218
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q07699 Pfam ID:PF07686
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Iota-conotoxin RXIA
Chain IDs:C (auth: D)
Chain Length:46
Number of Molecules:1
Biological Source:Conus radiatus
UniProt ID:Q7Z094
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
HYP C PRO modified residue
Ligand Molecules
9Z9
CLR
LPE
NA
NAG
P3X
P5S
PCW
Y01
Primary Citation
Diverse modulation mechanisms of human Nav1.6 by gating modifier neurotoxins
To Be Published ? ? ? (?)
Primary Citation of related structures
25II
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