ISDA: 25GF

Deposition Date 2026-04-01

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

25GF

Keywords:

SIGNALING PROTEIN

Title:

Cryo-EM structure of the human KPTN-ITFG2-C12orf66-SZT2(2189-3432) complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.81 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:KICSTOR complex protein kapti
Chain IDs:A
Chain Length:437
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:KICSTOR complex protein ITFG2
Chain IDs:C (auth: B)
Chain Length:447
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:KICSTOR complex protein SZT2
Chain IDs:D (auth: C)
Chain Length:1245
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:KICSTOR subunit 2
Chain IDs:B (auth: D)
Chain Length:445
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Mechanistic insights into GATOR1 inhibition by GATOR2 and KICSTOR

Yang, A, Liang, L.Show

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