ISDA: 24XP

Deposition Date 2026-03-23

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

24XP

Keywords:

NUCLEAR PROTEIN

Title:

Crystal structure of WDR5 F133A variant in complex with MBD3C

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.30 Å

R-Value Free:

0.17

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A, C (auth: B)
Chain Length:315
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61964 Pfam ID:PF25175

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Methyl-CpG-binding domain pro
Chain IDs:B (auth: C), D
Chain Length:12
Number of Molecules:2
Biological Source:Mus musculus

UniProt ID:24XP

Primary Citation

Water-mediated compensation preserves WIN motif binding in WDR5 aromatic mutants

Pan, Y, Li, H, Peng, S, Wang, H, Wu, Z, Hang, T, Liu, Y, Yang, Y.Show

Biochem.Biophys.Res.Commun. ? 153842 ? (2026)

DOI: 10.1016/j.bbrc.2026.153842

Primary Citation of related structures

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