24XN image
Deposition Date 2026-03-23
Release Date 2026-05-06
Last Version Date 2026-05-06
Entry Detail
PDB ID:
24XN
Keywords:
NUCLEAR PROTEIN
Title:
Structure of WDR5 F263A variant in complex with MBD3C
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.57 Å
R-Value Free:
0.21
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 1 21 1
24XN validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A, C (auth: B)
Chain Length:315
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P61964 Pfam ID:PF25175
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Methyl-CpG-binding domain pro
Chain IDs:B (auth: C), D
Chain Length:12
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:24XN
Primary Citation
Water-mediated compensation preserves WIN motif binding in WDR5 aromatic mutants
Biochem.Biophys.Res.Commun. ? 153842 ? (2026)
DOI: 10.1016/j.bbrc.2026.153842
Primary Citation of related structures
24XN
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