24HT image
Deposition Date 2026-03-04
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
24HT
Keywords:
SIGNALING PROTEIN
Title:
Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP2527
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.70 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 61
24HT validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12D
Chain IDs:A
Chain Length:179
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2
Protein Blast
Polymer Type:polypeptide(L)
Molecule:AP2527
Chain IDs:B (auth: I)
Chain Length:11
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
ACY
EDO
GDP
MG
Primary Citation
Structure-Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region
Acs Med.Chem.Lett. ? ? ? (2026)
DOI: 10.1021/acsmedchemlett.6c00122
Primary Citation of related structures
24HT
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