ISDA: 24HS

Deposition Date 2026-03-04

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

24HS

Keywords:

SIGNALING PROTEIN

Title:

Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP4959

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.53 Å

R-Value Free:

0.28

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12D
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:179
Number of Molecules:8
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Protein Blast

Polymer Type:polypeptide(L)
Molecule:AP4959
Chain IDs:I, J, K, L, M, N, O, P
Chain Length:12
Number of Molecules:8
Biological Source:synthetic construct

Ligand Molecules

EDO

GDP

Primary Citation

Structure-Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region

Chiyoda, A, Matsuo, A, Yamano, T, Tanada, M.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.6c00122

Primary Citation of related structures

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