ISDA: 24HR

Deposition Date 2026-03-04

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

24HR

Keywords:

SIGNALING PROTEIN

Title:

Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP6252

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.07 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.23

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12D
Chain IDs:A, B, C, D
Chain Length:179
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Protein Blast

Polymer Type:polypeptide(L)
Molecule:AP6252
Chain IDs:E (auth: I), F (auth: J), G (auth: K), H (auth: L)
Chain Length:12
Number of Molecules:4
Biological Source:synthetic construct

Ligand Molecules