24EW image
Deposition Date 2026-03-02
Release Date 2026-06-03
Last Version Date 2026-06-03
Entry Detail
PDB ID:
24EW
Title:
SARS-CoV-2 polymerase with incorporated and pre-incorporated AT-9052-Sp
Biological Source:
Method Details:
Experimental Method:
Resolution:
2.39 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RNA-directed RNA polymerase
Gene (Uniprot):rep
Chain IDs:E (auth: A)
Chain Length:956
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Non-structural protein 8
Gene (Uniprot):rep
Chain IDs:A (auth: B), F (auth: D)
Chain Length:220
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Non-structural protein 7
Gene (Uniprot):rep
Chain IDs:B (auth: C)
Chain Length:110
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*AP*UP*UP*AP*AP*GP
Chain IDs:C (auth: I)
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*CP*CP*CP*CP*AP*UP
Chain IDs:D (auth: J)
Chain Length:30
Number of Molecules:1
Biological Source:synthetic construct
Primary Citation
Consecutive catalytic steps of viral RNA polymerases and exonucleases suggest a way to overcome innate nucleotide analogue resistance
To Be Published ? ? ? (?)
Primary Citation of related structures
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