ISDA: 24BZ

Deposition Date 2026-02-27

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

24BZ

Keywords:

HYDROLASE

Title:

Crystal structure of nuclease MYG1(H55A) bound to Mn2+ and AMP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.91 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MYG1 exonuclease
Gene (Uniprot):MYG1
Mutagens:H55A
Chain IDs:A
Chain Length:327
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9HB07

Ligand Molecules

AMP

Primary Citation

Biochemical and structural studies reveal the substrate specificity and catalytic mechanism of MYG1 as a two-metal ion-dependent 3'→5' exonuclease.

Lan, C, Chen, Z, Wang, G, Ding, J.Show

Acta Biochim. Biophys. Sin. (Shanghai) ? ? ? (2026)

PMID: 41964352 DOI: 10.3724/abbs.2026058

Primary Citation of related structures

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