24BW image
Deposition Date 2026-02-27
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
24BW
Keywords:
HYDROLASE/RNA
Title:
Crystal structure of nuclease MYG1(D93A) bound to Mn2+ and UU
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.82 Å
R-Value Free:
0.22
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
C 2 2 21
24BW validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:MYG1 exonuclease
Gene (Uniprot):MYG1
Mutagens:D93A
Chain IDs:A
Chain Length:327
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9HB07
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*UP*U)-3')
Chain IDs:B (auth: C)
Chain Length:2
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
MN
Primary Citation
Biochemical and structural studies reveal the substrate specificity and catalytic mechanism of MYG1 as a two-metal ion-dependent 3'→5' exonuclease.
Acta Biochim. Biophys. Sin. (Shanghai) ? ? ? (2026)
PMID: 41964352 DOI: 10.3724/abbs.2026058
Primary Citation of related structures
24BW
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