ISDA: 24BG

Deposition Date 2026-02-26

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

24BG

Keywords:

FLAVOPROTEIN

Title:

Crystal structure of MonCI mutant N278R-S421A-Q441P

Biological Source:

Source Organism(s):

Streptomyces virginiae (Taxon ID: 1961)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.27 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:MonCI
Mutagens:N278R/S421A/Q441P
Chain IDs:A, B
Chain Length:511
Number of Molecules:2
Biological Source:Streptomyces virginiae

Ligand Molecules

FAD

Primary Citation

Co-evolution-guided engineering of monensin biosynthetic monooxygenase MonCI reveals mechanistic basis for concurrent stability and catalytic enhancement.

Xiao, H, Li, J, Zhou, J, Liu, C, Deng, Y, Wang, S, Tong, Z, Liu, J, Zheng, Z, Zhong, J, Li, H, Chen, X.Show

Int.J.Biol.Macromol. ? 154119 154119 (2026)

PMID: 42624264 DOI: 10.1016/j.ijbiomac.2026.154119

Primary Citation of related structures

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