23WU image
Deposition Date 2026-02-24
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
23WU
Keywords:
OXIDOREDUCTASE/DE NOVO PROTEIN
Title:
Crystal structure of monomeric Cu/Zn-superoxide dismutase in complex with de novo designed binder (#313-604)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.70 Å
R-Value Free:
0.34
R-Value Work:
0.29
R-Value Observed:
0.29
Space Group:
C 2 2 21
23WU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Superoxide dismutase [Cu-Zn]
Gene (Uniprot):SOD1
Mutagens:C6S, C57S, H63A, H80A, D83A, C111S, C146S
Chain IDs:A (auth: B), B (auth: A)
Chain Length:157
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P00441 Pfam ID:PF00080 EC:1.15.1.1
Polymer Type:polypeptide(L)
Molecule:SOD1 binder #313-604
Chain IDs:C (auth: D), D (auth: C)
Chain Length:102
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
ZN
Primary Citation
De novo designed binders suppress aggregation of Cu/Zn-superoxide dismutase implicated in amyotrophic lateral sclerosis
To Be Published ? ? ? (?)
Primary Citation of related structures
23WU
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